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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6d98399b5b3faf6047c0219cddc0ee3454557bd1085f3cdd34c7f3dd3277f2e5' 
  AND token = 'WVVpfxpHVPoTF0YDMMV4NGPFt3uU3rg5ocnUMRh2fQs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}