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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed321bd80542532215cb85c82caac5b7be939f0ad709c566daea03060e863578' 
  AND token = 'u8lVyIeWXjKuvwvTrXGwFxepYEdWYhAJNM0geD/tKvQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00056

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}