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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a53eff2539687973847c86bfef49f76ab3d896439edf46d1f3187fefecaf8c82' 
  AND token = 'Z6u4Eu8P2HYaiDYs/NiA8hRDjIh+DURUoXcMtu6KFHA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}