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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6a266109f47c47c0e30640517b64ff5a2e52f0b758718f010d5ec03c7a24056c' 
  AND token = 'Tt+I79E+XF4FfKxrHNLGDUnWW1uPZaQC7XSYoUWPqSc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}