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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2454124bf095332038c149a9dfe670d65fb0ac003d93f8f0429790a21c02c9d0' 
  AND token = 'vF8GOsA1my5G1CoJliE3yrv786pNb+/O59KeaKCx3qo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}