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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25140e7d8b90a9c4fbeb28365f82119ae939703c3a58e60e5f56e30e9930597b' 
  AND token = 'E43ZNnHHa4MzaRFqUv2yH6xo5EFGo+c7RXXWUZY5IpY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}