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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '648e6cc15961ed7ca4598567233cc3d6921f3d35a9e9b243cfb5c0ef27f270f0' 
  AND token = 'ADD58WOmpDYFgUv5N3FAiqCF9pVyt2DvfZ1Cu205ozA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00047

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}