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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c8e0bce28d3ae372309213eac72ca9c6cb235e32e5b40b79d6f6b9dd3d212e41' 
  AND token = 'NcZrLWuT2m3kY3oj6+IEFtu0dwechEm2DFFO8IsyjEo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}