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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f87285e016a7c00f98fc1f7a48d8413ad88649c20f186fded492eb391afb566d' 
  AND token = 'XQ2xR4lCnPSGuox3fFEBiqWZk4qUi0jCRPOsoE52mV4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}