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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8be4be4dac6790432045b57b2aa16df87e4343b2a5aa3d286a27a354f23829f5' 
  AND token = '8pVoaYuMzHNuY6STNZvajr+xBmWavIoE9vMJgfAMSwk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}