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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81349a2e56fc7e42eacccd30138e21b57b2749929d23396da98005703b20fc2d' 
  AND token = 'YKS4JP3XVsZFwejjeGSUL0MdZIaq058DZCBFavcBMqM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}