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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2581ed645fab54c64c64a0a1bc9997021ece1208227fe21df83020bc35c04428' 
  AND token = 'EIkiFnxDpwx0IQ5eHxFi4qDyPlR0Dk/waFX+vZ66BNQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00051

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}