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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '68e20cfa377451c6da7738fa69a43d1c16a493b54e54a6e2e2897b3c4c3dcb06' 
  AND token = 'kh9So+yGR4RR45y8FfbQdtk1fOSU6ApneMZ6M8amQMo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}