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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a69181e20c372a1338020f3d8d1f1f34d0f34468e8f8b67012059a9c76d5a40e' 
  AND token = 'zxWv/FYwUA/elEbxNnnDhrd+tT4aNDpM2CUpRwFvgE0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}