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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '581187aa8daf0b6ca8cffe847ed0e7f86e0c95a801dded7118c0f6208fa82b42' 
  AND token = 'd5DI+7gRjc6HT/D7sRx5jhZipBAvlKW4TFxYGwa5SiA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}