SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2cf1924eabee3b16d565428c3c6d07c2057d130251a6baa5dd152f1a29b8e54c' 
  AND token = '1nIOhQyo/4GzB8uW7nC3QBE0wCyeK7gWyWxGl1cCXfI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}