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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5f509db1833652f0501a017df8ded6f11bdbbd4caec2c1e3ad55987e9eb7aabd' 
  AND token = 'Y2c+ySMc3ec7aEdT61b0WRmdWRO/OHlz6dz3D6aQQEM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}