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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '374ec1449cc128576e07391217d9b5dc77390b09db912c956f606733373f6e6f' 
  AND token = 'A5Z7EP1xERYktLBmU9Zav+8qvQfqTLrOZ/JCm/+1/FI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}