SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0143157dd420521b5825312cf82e70c138e4220098e1c7177ef0431500d685bb' 
  AND token = 'ic25XWA7/UiPC8D2VR0gEgv5JMnMPgXHkZI2MwPWsl8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}