SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '777937cb461d3d6694631e78d0cf8c3d93bef5b77ea69dc42ece3e982584322d' 
  AND token = 'LcwsumeB39JwCOFbxqfLV6mA/D0NbNeRIoI5rL++8sY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}