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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '427daf3c1d119f59791433dd19abf65c6f4cc7c3995effa231be1d18d34339d5' 
  AND token = 'E+Ws5m65XXRZSUUDr5I3QcbOR/J/jygJoZsrwS8K5nA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}