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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5304795b43bb09ee23196854f0f064d3a49be65bbf91bf57785b50ebd83e4bd2' 
  AND token = 'HwBx4hi8eo3pGE12v4oZyy7rOApsBfGmlnA63tF6Z1Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}