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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0b4fb6709e0bf111ea313e94a8ac7392f3949de09d64e65f66ee33ff5e0e1471' 
  AND token = 'JhmCd55lUpm0H4edakIT9Bx0PfTeGjHXUn9BGMZuCEg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}