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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '972f0467fb2dc53027a5aa2b0de4c5294d8086218dcb2aba35cc7c4b4c214e00' 
  AND token = 'RUibWq7cnOPNGfdNSfUrwvSAwrCvbeA/cvXqXICwD6w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}