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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43fcec4bfe5e5d031690a2716e69b05f8b16d369a77afd34d12368dbb1cd4a2a' 
  AND token = 'obp0BL9K5DFj4Qcurai++cROyLnBUKpP+p5VcxAB/+A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}