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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5c8154ffd122e5e7397573f9db4e48451a01b2004aa7c3996f48bc53d3cb1802' 
  AND token = 'mxQnpe25ljEtDNa+3lED9ny7dFw8S2o63zM4W6CJw8g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}