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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25136cc4f9530c50d1a078e1d65bd0822f59ea94fab0414cdef9e94c2d54c8c6' 
  AND token = '+Qn46h3R8oZDWFfy6mpZPkEocB4aU8/LLfdJrkX4GbU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}