SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c25b938838e1cedd96980e7cee23d8bacc291671bda81cb7cec42b764f800875' 
  AND token = 'IP0ZrifjGKo0RkkTUekL6+fGrWEIYFia2fMRNcSFeMY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}