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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'aa2270fead44ce45eb137c64726dd53ea382eedc5be4c529a176c370a498afab' 
  AND token = 'DaC7MTUe788VBVQ/bNsLkx0mPI/fBkvWnRhIbsVNAQw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}