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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5b8b75dd31ee6fc108f2b149ccf09100fd24fe15c4de4612510d0e814670f0d6' 
  AND token = 'zRgcC6PgX7gvlU0NhDKbMb7kdVMVgbtpnVxtrzcoTyI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}