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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4221a1f20d045e871fa61c75b3c2b5b0e0662e6ba879054108436b3391ed3f38' 
  AND token = 'ftnBL6xj6NQE3C9FrBcYY4tFGzCrHf72aiCuVgZg+m8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}