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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7b5aff021b5e209bd2f5bd5d1ce697629e05a73b68410108dd42dd0105dc46a4' 
  AND token = 'R9IK0K7jcdBC1vFnNJTceGHh7XHAxn4WFcwV/qgWY9Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}