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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '442f633cf2dd1285b94e009994fa71ff7816c7476e1c44e78c1b29b5060b1106' 
  AND token = 'ze4SxhcSWbwGfcrcBdeO+RQBMUBk2d7qEV2h4/VBQqM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}