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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5000210a6b2e8a36cc5b71f9c55ed9accdc2f223bc6439cc54f3f552353c0253' 
  AND token = '0R/auXvG7jGyRZCOom8XLjfrpu7rMiGbTHiiqCNN6Vg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}