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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1872ce26689e97d286c9c5e2434cfa27b16f7a29959a6268591a334666018c35' 
  AND token = '5NI15z2Ac0Y2bvHLCQtzKX7czSVemFD+EZYixtVcCLQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}