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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8526f90bdac03caf887e17c35633d3d8a301c9159658fbff1e1476a8b7ad1f8d' 
  AND token = 'pR8i/8vTI5UMHb/p+1gdfvQut1RcnAECuMj5RlOPMJQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}