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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0c649f06e94e8cfee5236453c16988c44acc5bb9aa066a44c645a088e7d40521' 
  AND token = 'KrKm0WNw8+68jkvexDCyKZfg9xTXFsj8h38ev/tC3uM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}