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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4ae6439026f63816f944cb76449846247d8154468eb09be600df36780ed7778a' 
  AND token = 'KkpxMibA/5/EGR7XxcFhiNCtMvV9HzKXyCmxZDQBN9g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}