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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '757d39ebaf5fdcca351fff18a64c148d9fc3d6351375fc43db5fb391ebac15bf' 
  AND token = 'x+gGcSQw1COB5Lv2mCUkUoGpJTIC6iVcZGb6WGk1Yk4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}