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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2220aa528e66c077701e1dc64f42aec64a00c9da93aa9194f3631fa37336552b' 
  AND token = '4r+dJ0wcWxbccAqrB+ixBQ8GZSFyo98Ygozw1vNRHho=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}