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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52a368780c832e73e3021625f7cf965737a59c03918a60e48b50acbfc43add8a' 
  AND token = 'n2GHk8b4N7Wh6yCeDB8WM+OlMWNxWRPA1XGxyXx4IhE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}