SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e9ea12e250c8587709b1a0bf43610c4395ab294027cd8bf7a6a9255f8d2a3369' 
  AND token = 'vqmDsBBP9oR9EvKuwLdRM6/CaTtgMmA6bhfQ0OH1RVA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}