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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9a6a3c08ad24c4100afb2b344980ff7a9d408a9901ee3788a2495b76a2160e65' 
  AND token = 'Osd0kTx44+bccMBsbqEaajVMHJLU5H6MTlkjIeOs9UM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}