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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1e2ee8a3ce5697d32079c643a8b21e07b790c2b6a5d4de72151d995ef34ba33b' 
  AND token = 'iGj/MI33VN8Ud7LOIFgrBopVrpaJk7xBZ/rfF1qWgsk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}