SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c721ae45f4e8b459a0228474cf3ffe0e3977906cc0fdd0712769bd6ff2083af5' 
  AND token = 'ZQRPXzfWzsxYCFcpqUoFM/d9mpBoiICnn5HYHYWbsxY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}