SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2625d84120a2fdeab689fce29ed465b21e61cfbd7a37264e4b24af03a3e706bb' 
  AND token = 'yZ6V1Mwds1NeOHcFW0sCCQYM6DcrIAFEVej29ILPBDQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}