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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46cd780db89657622439c0492ccb929f21ca04e6080a269571336c6ae6088afa' 
  AND token = 'XuIsMYS+yeluh1MMtd1VAMHAnalKQqgW6EYEZgMp1Cs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}