SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6337a6fd9a0f9d2f68771df96fafa2cc521e3ad378da85e30a9667fc4b43267b' 
  AND token = '2lwk2YxblE3oiXVBhLXu3IM3tkgzM19liF8TvxrzvIM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}