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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '777ede4b206185484ddbdb302a6e4f1e4db6b9a6390376121f2ff77db13147f9' 
  AND token = 'np2Jtkc4MDHrhBLi9tzy+FElQb4mLpi9pQ8B016Xm6k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}