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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42463c8d12720dd1146d9dcdd8f21f054ffd221a4a8e24cf66b0a921de04b953' 
  AND token = 'PSyLdCGSsE749hA3o3DT2AkxezmiGLugNQXDi38WA9I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}